Deutsch 
Test-Category
HPLC
Detection
UV detection
Elution
isocratic
Pack size
100 Tests
Possible sample matrix and volumes
| EDTA plasma | 200 µl |
| EDTA whole blood | 200 µl |
| Serum | 200 µl |
Ubiquinone was first isolated in the 50th by the group of Prof. Green (Wisconsin). The function was investigated by Prof. Mitchel, who received the Nobel price for his research on the oxydative phosphorylation pathway.
Ubiquinone is a coenzyme which is represented in every cell and the whole metabolism. It is built up by a chinonic ring and an isoprenic sidechain. In humans ubiquinone can be synthesized and taken up by nutrition.
Ubiquinone has two different pysiological functions.
1.) Component of the energy metabolism
2.) Radical scavanger
During the reduction of oxygen in the oxydative phosphorylation 3 Mol ATP are generated. In this reduction electrons are tranferred from NADPH to oxygen via 6 different redox systems. Ubiquinone is the less abundant redox system in the membrane of the mitochondria. Because of the low amount it is the speed controlling redox-system in the energy metabolism. Normally the amount of ubiquinone is sufficient, but with growing age and exposure to sunlight it is reduced to 50%.
Ubiquinone has a high number of carbon-carbon double bonds and therefore a higher potential of reduction than vitamin C or vitamin E. Thereby it is the first line of defense against free radicals. Therefore ubiquinone is an optimal stabilizer of the ion channels of the membranes.
