Deutsch 
Test-Category
ELISA
Pack size
Standard concentrations included in the kit
0.16-10 µg/ml
Possible sample matrix and volumes
| Serum | 50 µl |
| Thymus extract | 50 µl |
Incubation periods
Indications
Regulatory Status
The beta-thymosins are a family of highly conserved polar 5 kDa peptides originally thought to be thymic hormones. Further studies demonstrated that the molecule is ubiquitous; it had been found in a variety of tissues and cell lines. It is found in highest concentrations in spleen, thymus, lung, and peritoneal macrophages. Thymosin beta 4 binds monomeric actin in a 1:1 complex and act as actin buffers, preventing polymerization into actin filaments but supplying a pool of actin monomers when the cell needs filaments. Changes in the expression of thymosin beta 4 appear to be related to the differentiation of cells. Thymosin beta 4 is detected outside of cells in blood plasma or in wound fluid. Several biological effects are attributed to thymosin beta 4, like induction of metallo-proteinases, chemotaxis, angiogenesis and inhibition of inflammation as well as the inhibition of bone marrow stem cell proliferation.
