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Test-Category
ELISA
Pack size
96 Determinations
Standard concentrations included in the kit
0.1-4.0 µmol/l
Possible sample matrix and volumes
| Serum | 50 µl |
| EDTA plasma | 50 µl |
| Li-heparin plasma | 50 µl |
Incubation periods
Indications
Regulatory Status
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Endogenous marker of renal dysfunction
The dosage of most drugs must be adapted in renal insufficiency, making accurate assessment of renal function a prerequisite in clinical practice. Furthermore, even a modest decline in renal function has been recognized as a cardiovascular risk. Serum creatinine is typically used to asses renal function, but does not increase at modest decline in renal function. Consequently, there is an ongoing search for suitable endogenous markers of renal function. SDMA is a methylated derivative of L-Arginine which is strictly eliminated by renal extraction. Therefore, SDMA plasma level is strongly correlated to renal function. Moreover, there are hints that increased SDMA correlates with total sequential organ failure indicating both renal and hepatic failure and an increased cardiovascular risk.
