Deutsch 
Test-Category
ELISA
Pack size
96 Tests
Standard concentrations included in the kit
0.62-40 kU/l
Possible sample matrix and volumes
| Serum | 20 µl |
| Stool | 15 mg |
Immunoglobulin E (IgE) has been demonstrated in several human secretions and fluids, such as repiratory tract mucus and saliva, urine, tears, human milk as well as in intestinal juices. The IgE is responsible for various hypersensitivity reactions of the immediate type (Type-I-hypersensitivity). Polyvalent antigens trigger B-cells to produce specific IgE in large amounts. The released IgE antibodies bind to the Fc receptor on the surface of mast cells. The next time the sensitized person has contact to the allergen, it crosslinks the IgE on the surface of the mast cells and thereby triggers the mast cells to release histamine, which cause the various symptoms. IgE is involved in a number of allergic phenomena such as erythema, anaphyllaxis, homocytotropic histamine release, skin-sensitization and atopic reaction. In patients suffering from allergy, the IgE levels increase as much as three to four times compared to the healthy.
